Join Us

We are looking for a highly motivated Scientist (Postdoctoral Fellow) and a Research Officer to join our team and contribute to innovative RNA- and DNA-targeted therapeutic discovery. For inquiries or to apply, please email your CV and brief research interest to Zutao Yu at zy323@cam.ac.uk with the email title “Scientist/Research Officer Application_ASTAR”.

We welcome visiting scholars and students interested in chemical biology, nucleic acids, and genomic medicine. If you’re passionate about cutting-edge research in these areas, we encourage you to join us!

🧪 Scientist / Senior Scientist (fully funded, instantly available)

Responsibilities:

• Design and execute functional genomics experiments, including CRISPR-, small molecule-, and ASO-based gene regulation strategies.
• Develop and refine chemical biology approaches to investigate DNA- and RNA-small molecule interactions.
• Integrate transcriptomics and genomics data to study small-molecule targeting at the transcriptome and genome level (prior experience is a plus but not required).
• Collaborate with biologists and chemists to identify RNA-targeting ASOs and small molecules with therapeutic potential.
• Lead research projects, mentor junior researchers, and contribute to manuscripts and grant writing.

Requirements:

• 🎓 PhD in Biology, Chemical Biology, Genetics, or a related field.
• 🔬 Strong expertise in wet lab research, including molecular biology, RNA biology, chemical biology, or functional genomics.
• 🧬 Experience in nucleic acids research, CRISPR-dCas9/13 approaches, chemical design, or sequencing technologies.
• 📖 Strong scientific writing, presentation, and project management skills.
• 🤝 Highly motivated, collaborative, and eager to explore innovative therapeutic strategies.

🧬 Research Officer (fully funded, instantly available)

Responsibilities:

• Develop and optimize cellular assays to evaluate the efficacy of RNA-targeting strategies in cells.
• Assist in designing and conducting experiments related to CRISPR, small-molecule screening, and ASO development.
• Perform molecular biology experiments, including CRISPR-based gene regulation, plasmid construction, stable cell line establishment, and RNA-seq library preparation.
• Maintain lab operations, including reagent preparation, consumable ordering, budget tracking, and equipment maintenance.
• Engage in literature reviews, research discussions, and collaborative projects.
• Ensure project milestones are met and contribute to manuscript preparation.

Requirements:

• 🎓 Degree in Biological Sciences, Chemical Biology, or related fields.
• 🔬 Experience in molecular biology, cell culture, RNA biology, CRISPR, or sequencing technologies.
• 🧠 Strong organizational skills and a positive, eager-to-learn attitude.
• 🤝 Ability to work both independently and collaboratively in a fast-paced research environment.

🌟 Why Join Us?

The Genome Institute of Singapore (GIS), A*STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation. GIS offers a highly competitive remuneration package and relocation assistance. Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation.

Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine! 🚀